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Article

Construction and characterization of ribonuclease H2 C subunit-knockout NIH3T3 cells.

Bioscience, biotechnology, and biochemistry - 24 Jul 2023

Hara Haruka, Yano Haruna, Akazawa Kaho, Kamoda Kana, Kandabashi Mako, Baba Misato, Takita Teisuke, Yasukawa Kiyoshi

Abstract excerpt

Mammalian ribonuclease (RNase) H2 is a trimer consisting of catalytic A and accessory B and C subunits. RNase H2 is involved in the removal of misincorporated ribonucleotides from genomic DNA. In humans, mutations in RNase H2 gene cause a severe neuroinflammatory disorder, Aicardi-Goutières syndrome (AGS). Here, we constructed RNase H2 C subunit (RH2C)-knockout mouse fibroblast NIH3T3 cells. Compared with the...

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Identifiers

PMID: 37291694
DOI: 10.1093/bbb/zbad077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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