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Article

RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

The Journal of experimental medicine - 7 Mar 2016

Pokatayev Vladislav, Hasin Naushaba, Chon Hyongi, Cerritelli Susana M, Sakhuja Kiran, Ward Jerrold M, Morris H Douglas, Yan Nan, Crouch Robert J

Abstract excerpt

The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several nucleotide-processing proteins, including RNase H2. Defective RNase H2 may induce accumulation of self-nucleic acid species that trigger chronic type I interferon and inflammatory responses, leading to AGS pathology. We created a knock-in mouse model with an RNase H2 AGS mutation in a highly...

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Identifiers

PMID: 26880576
DOI: 10.1084/jem.20151464
PMCID: PMC4813680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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