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Article

A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.

Andrology - 1 Feb 2024

Shan Xudong, Zhang Xueguang, Huang Gelin, Lv Jiao, Ye Zixia, Jiang Chuan, Jiang Xiaohui, Cheng Jianxing, Lin Haocheng, Jiang Hui, Yue Huanxun, Wang Zhengrong, Xu Wenming

Abstract excerpt

BACKGROUND: The ubiquitin ligase HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 is essential for the establishment and maintenance of spermatogonia. However, the role of HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 in regulating germ cell differentiation remains unclear, and clinical evidence linking HECT, UBA, and WWE domain-containing E3 ubiquitin protein ligase 1 to...

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Identifiers

PMID: 37290064
DOI: 10.1111/andr.13474

Genes

HUWE1
STRA8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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