Article
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Scientific reports - 5 Mar 2015
Li Zesong, Huang Yi, Li Honggang, Hu Jingchu, Liu Xiao, Jiang Tao, Sun Guangqing, Tang Aifa, Sun Xiaojuan, Qian Weiping, Zeng Yong, Xie Jun, Zhao Wei, Xu Yu, He Tingting, Dong Chengliang, Liu Qunlong, Mou Lisha, Lu Jingxiao, Lin Zheguang, Wu Song, Gao Shengjie, Guo Guangwu, Feng Qiang, Li Yingrui, Zhang Xiuqing, Wang Jun, Yang Huanming, Wang Jian, Xiong Chengliang, Cai Zhiming, Gui Yaoting
Abstract excerpt
Non-obstructive azoospermia (NOA), a severe form of male infertility, is often suspected to be linked to currently undefined genetic abnormalities. To explore the genetic basis of this condition, we successfully sequenced ~650 infertility-related genes in 757 NOA patients and 709 fertile males. We evaluated the contributions of rare variants to the etiology of NOA by identifying individual genes showing nominal...
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