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Article

Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin-Drug Conjugate Response.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2023

Hu Huiyu, Ng Thomas S C, Kang Mikyung, Scott Ella, Li Ran, Quintana Jeremy M, Matvey Dylan, Vantaku Venkata R, Weissleder Ralph, Parangi Sareh, Miller Miles A

Abstract excerpt

PURPOSE: Oncogene-driven macropinocytosis fuels nutrient scavenging in some cancer types, yet whether this occurs in thyroid cancers with prominent MAPK-ERK and PI3K pathway mutations remains unclear. We hypothesized that understanding links between thyroid cancer signaling and macropinocytosis might uncover new therapeutic strategies. EXPERIMENTAL DESIGN: Macropinocytosis was assessed across cells derived from...

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Identifiers

PMID: 37289199
DOI: 10.1158/1078-0432.CCR-22-2976
PMCID: PMC10527034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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