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Article

Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE.

Autophagy - 1 Oct 2023

Zhang Yuelu, Huang Jiancheng, Liang Yu, Huang Jiaqiu, Fu Yuhua, Chen Ningxie, Lu Boxun, Zhao Chen

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly, and there is currently no clinical treatment targeting the primary impairment of AMD. The earliest clinical hallmark of AMD is drusen, which are yellowish spots mainly composed of lipid droplets (LDs) accumulated under the retinal pigment epithelium (RPE). However, the potential pathogenic role of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37266932
DOI: 10.1080/15548627.2023.2220540
PMCID: PMC10472852

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