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Article

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2006

Guillem José G, Wood William C, Moley Jeffrey F, Berchuck Andrew, Karlan Beth Y, Mutch David G, Gagel Robert F, Weitzel Jeffrey, Morrow Monica, Weber Barbara L, Giardiello Francis, Rodriguez-Bigas Miguel A, Church James, Gruber Stephen, Offit Kenneth

Abstract excerpt

Although the etiology of solid cancers is multifactorial, with environmental and genetic factors playing a variable role, a significant portion of the burden of cancer is accounted for by a heritable component. Increasingly, the heritable component of cancer predispositions has been linked to mutations in specific genes, and clinical interventions have been formulated for mutation carriers within affected...

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Identifiers

PMID: 17008706
DOI: 10.1200/JCO.2005.04.5260

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