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Article

Evaluation of FTO polymorphism in 6-mercaptopurine related intolerance in children with acute lymphoblastic leukemia.

Cancer chemotherapy and pharmacology - 1 Jul 2023

Singh Minu, Bhaskar Divya, Bhatia Prateek, Thakur Rozy, Sharma Pankaj, Bansal Deepak, Jain Richa, Trehan Amita

Abstract excerpt

PURPOSE: Thiopurine drugs like 6-Mercaptopurine (6MP) are the cornerstone of maintenance therapy in acute lymphoblastic leukemia (ALL). A recently described variant in alpha-ketoglutarate dependent dioxygenase (FTO) gene has been reported to play an important role in thiopurine induced myelosuppression. METHODS: In this study, we genotyped a coding variant (p.Ala134Thr, rs79206939) and an intronic variant...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37256334
DOI: 10.1007/s00280-023-04546-3

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