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Concomitant knockdown resistance allele, L982W + F1534C, in Aedes aegypti has the potential to impose fitness costs without selection pressure.

Pesticide biochemistry and physiology - 1 Jun 2023

Uemura Nozomi, Furutani Shogo, Tomita Takashi, Itokawa Kentaro, Komagata Osamu, Kasai Shinji

Abstract excerpt

The Aedes aegypti mosquito, is an arbovirus vector that can spread dengue, chikungunya, Zika, and yellow fever. Pyrethroids are widely used to control mosquitoes. The voltage-gated sodium channel (Vgsc) is the target of pyrethroids, and amino acid substitutions in this channel attenuate the effects of pyrethroids. This is known as knockdown resistance (kdr). Recently, we found that Ae. aegypti with concomitant...

Topics

Animals
Insecticides
Aedes
Alleles
Insecticide Resistance
Pyrethrins
Mutation
Voltage-Gated Sodium Channels
Zika Virus
Zika Virus Infection
Mosquito Vectors

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PMID: 37247997
DOI: 10.1016/j.pestbp.2023.105422

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