Article
Establishment of an innovative and sustainable PCR technique for 1534 locus mutation of the knockdown resistance (kdr) gene in the dengue vector Aedes albopictus.
Parasites & vectors - 26 Dec 2019
Zhu Cai-Ying, Zhao Chun-Chun, Wang Yi-Guan, Ma De-Ling, Song Xiu-Ping, Wang Jun, Meng Feng-Xia
Abstract excerpt
BACKGROUND: Mutation of the voltage-gated sodium channel (VGSC) gene, or knockdown resistance (kdr) gene, is an important resistance mechanism against DDT and pyrethroids for dengue vector Aedes albopictus. A phenylalanine to serine (F1534S), leucine (F1534L) and cysteine (F1534C) substitution were detected in many Ae. albopictus populations around the world, and the mutant allele frequencies have been increasing...
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