Article
A multiplex PCR for detection of knockdown resistance mutations, V1016G and F1534C, in pyrethroid-resistant Aedes aegypti.
Parasites & vectors - 10 Oct 2017
Saingamsook Jassada, Saeung Atiporn, Yanola Jintana, Lumjuan Nongkran, Walton Catherine, Somboon Pradya
Abstract excerpt
BACKGROUND: Mutation of the voltage-gated sodium channel (VGSC) gene, or knockdown resistance (kdr) gene, is an important resistance mechanism of the dengue vector Aedes aegypti mosquitoes against pyrethroids. In many countries in Asia, a valine to glycine substitution (V1016G) and a phenylalanine to cysteine substitution (F1534C) are common in Ae. aegypti populations. The G1016 and C1534 allele frequencies have...
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