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Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance Targets

10 May 2023

Abstract excerpt

Trichomonas vaginalis is the most common non-viral sexually transmitted infection. 5-nitroimidazoles are the only FDA-approved medications for T. vaginalis treatment. However, 5-nitroimidazole resistance has been increasingly recognized and may occur in up to 10% of infections. We aimed to delineate mechanisms of T. vaginalis resistance using transcriptome profiling of metronidazole (MTZ)-resistant and sensitive...

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PMID: 37242362
DOI: 10.3390/pathogens12050692

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