Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis

16 Dec 2011

Abstract excerpt

Metronidazole (MTZ), the FDA-approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance, while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen piperidine dithiocarbamate hybrids of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethane (8-20) were designed to potentiate the MTZ framework against drug resistance and sperm. New compounds were 1.2-12.1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Reproductive Health and Contraception
Share to Reproductive System and Pregnancy
Share to Reproductive tract infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24900434
DOI: 10.1021/ml200161t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR AnalysisPMID 24900434Read ↗

Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance TargetsSemantic proximity Read ↗

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatidsSemantic proximity Read ↗

Epigenetic reprogramming restores metronidazole sensitivity in drug-resistant <i>Trichomonas vaginalis</i> parasitesSemantic proximity Read ↗

Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolatesSemantic proximity Read ↗

Review of Experimental Compounds Demonstrating Anti-Toxoplasma ActivitySemantic proximity Read ↗

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational ModelsSemantic proximity Read ↗

Anthelmintic drug discovery: into the future.Semantic proximity Read ↗

Biological perspective of thiazolide derivatives against Mpro and MTase of SARS-CoV-2: Molecular docking, DFT and MD simulation investigationsSemantic proximity Read ↗

A Brief Review of Drug Discovery Research for Human African TrypanosomiasisSemantic proximity Read ↗

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasitesSemantic proximity Read ↗

Novel Tetrazole-Based Antimicrobial Agents Targeting Clinical Bacteria Strains: Exploring the Inhibition of Staphylococcus aureus DNA Topoisomerase IV and GyraseSemantic proximity Read ↗

1,2,3‐Triazole hybrids with anti‐HIV‐1 activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.