Article
Genetic Indicators of Drug Resistance in the Highly Repetitive Genome of Trichomonas vaginalis.
Genome biology and evolution - 1 Jun 2017
Bradic Martina, Warring Sally D, Tooley Grace E, Scheid Paul, Secor William E, Land Kirkwood M, Huang Po-Jung, Chen Ting-Wen, Lee Chi-Ching, Tang Petrus, Sullivan Steven A, Carlton Jane M
Abstract excerpt
Trichomonas vaginalis, the most common nonviral sexually transmitted parasite, causes ∼283 million trichomoniasis infections annually and is associated with pregnancy complications and increased risk of HIV-1 acquisition. The antimicrobial drug metronidazole is used for treatment, but in a fraction of clinical cases, the parasites can become resistant to this drug. We undertook sequencing of multiple clinical...
Topics
- Antiprotozoal Agents
- Drug Resistance
- Female
- Genome, Protozoan
- Humans
- Linkage Disequilibrium
- Phylogeny
- Polymorphism, Single Nucleotide
- Protozoan Proteins
- Recombination, Genetic
- Trichomonas Vaginitis
- Trichomonas vaginalis