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Article

Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond.

Genes - 22 May 2023

Pușcaș Alexandra Dana, Morar Iulia Ioana, Vesa Ștefan Cristian, Cătană Andreea, Pușcaș Cristian, Ilieș Roxana Flavia, Orasan Remus-Ioan

Abstract excerpt

Psoriasis is a systemic inflammatory disease that associates with multiple comorbidities. It involves complex interactions between environmental factors and polygenic predisposition. The IL-17 family is one of the main actors in the pathogenesis of psoriasis. Secondary nonresponse is common, especially during the long-term use of TNF-α inhibitors, but it is not uncommon even for newer biologics, such as IL-17...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37239484
DOI: 10.3390/genes14051123
PMCID: PMC10218648

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