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Article

The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis.

Pharmacogenomics - 1 Jan 2015

Prieto-Pérez Rocío, Solano-López Guillermo, Cabaleiro Teresa, Román Manuel, Ochoa Dolores, Talegón María, Baniandrés Ofelia, López Estebaranz José Luis, de la Cueva Pablo, Daudén Esteban, Abad-Santos Francisco

Abstract excerpt

Psoriasis improves when IL-17 is blocked. Anti-TNF drugs reduce the IL-17 signaling pathway, and anti-IL-17 drugs are being developed to treat moderate-to-severe psoriasis. We analyzed three SNPs in IL-17A (rs2275913 and rs10484879) and IL-17F (rs763780) to look for an association with psoriasis and/or with response to anti-TNF drugs or ustekinumab. We included 197 healthy controls and 194 patients with...

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PMID: 26415694
DOI: 10.2217/pgs.15.107

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TNF

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The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis.PMID 26415694Read ↗

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