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Article

Ex vivo exposure to p,p'-DDE decreases human macrophage polarization to the M1 phenotype.

Toxicology - 1 Dec 2025

Palacios-Valladares José R, Ortiz-Robles Christian D, Cupul-Uicab Lea A, Rivera-Maya Omar B, Hernández-Kelly Luisa C, García-Hernández Rosa M, Gómez Rocio, Cebrián Mariano E, Calderon-Aranda Emma S

Abstract excerpt

Evidence from cellular and animal model studies has shown that p,p-dichloro-diphenyl-trichloroethane (p,p'-DDT) and p,p-dichloro-diphenyl-dichloroethylene (p,p'-DDE) negatively affect the macrophage's inflammatory response and resistance to pathogen infections. Still, no evidence is available on the p,p'-DDE effects on human macrophages, even though there is a translational value to human public health. This...

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Identifiers

PMID: 40783014
DOI: 10.1016/j.tox.2025.154259

Genes

DDT
CD68
TNF

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