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Article

Inhibition of HDAC6 activity in kidney diseases: a new perspective

25 Jun 2018

Abstract excerpt

Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme that plays important roles in many biological processes, is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups from proteins. HDAC6 stands out from the other members of this family because it almost exclusively deacetylates cytoplasmic proteins and exerts deacetylation-independent effects, which has led to the...

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Share to Adenosine and Purinergic Signaling
Share to Histone Deacetylase Inhibitors Research
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PMID: 30134806
DOI: 10.1186/s10020-018-0027-4

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