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Toxin-antitoxin Genes Expression in Multidrug-resistant Mycobacterium tuberculosis Isolates under Drug Exposure.

Infectious disorders drug targets - 1 Jan 2023

Khosravi Azar Dokht, Savari Mohammad, Khoshnood Saeed, Shahi Fatemeh, Farshadzadeh Zahra

Abstract excerpt

INTRODUCTION: Toxin-antitoxin systems (TAs) are highly conserved in Mycobacterium tuberculosis (Mtb). The TAs role in maintaining and disseminating drug resistance in bacterial populations has been indicated. So, we aimed to analyze the expression level of mazEF-related genes in drugsusceptible and multidrug-resistant (MDR) Mtb isolates under isoniazid (INH) and rifampin (RIF) stress. METHODS: We obtained 23 Mtb...

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PMID: 37226796
DOI: 10.2174/1871526523666230524144448

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