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Article

MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs.

Nature communications - 22 Jan 2015

Tiwari Prabhakar, Arora Garima, Singh Mamta, Kidwai Saqib, Narayan Om Prakash, Singh Ramandeep

Abstract excerpt

Toxin-antitoxin (TA) systems are highly conserved in members of the Mycobacterium tuberculosis (Mtb) complex and have been proposed to play an important role in physiology and virulence. Nine of these TA systems belong to the mazEF family, encoding the intracellular MazF toxin and its antitoxin, MazE. By overexpressing each of the nine putative MazF homologues in Mycobacterium bovis BCG, here we show that Rv1102c...

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Identifiers

PMID: 25608501
DOI: 10.1038/ncomms7059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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