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Genetic liability to multi-site chronic pain increases the risk of cardiovascular disease.

British journal of anaesthesia - 1 Aug 2023

Lin Liling, Lin Jianwei, Qiu Junxiong, Liufu Ning, Lin Shishi, Wei Feng, Liu Qingping, Zeng Jingxian, Zhang Mingzhi, Cao Minghui

Abstract excerpt

BACKGROUND: Observational studies have shown associations between multi-site chronic pain (MCP) and cardiovascular disease. However, it remains unclear whether these associations are causal. Therefore, this study aimed to assess the causal associations between MCP and cardiovascular disease and identify possible mediators between them. METHODS: A two-sample Mendelian randomisation analysis was applied in this...

Topics

Humans
Cardiovascular Diseases
Genome-Wide Association Study
Chronic Pain
Genetic Predisposition to Disease
Risk Factors
Coronary Artery Disease
Myocardial Infarction
Heart Failure
Stroke

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 37225534
DOI: 10.1016/j.bja.2023.04.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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