Associations of chronic pain and genetic risks with incident atrial fibrillation: a prospective cohort study.

doi:10.1186/s12872-026-05994-4

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Article

Associations of chronic pain and genetic risks with incident atrial fibrillation: a prospective cohort study.

BMC cardiovascular disorders - 1 Jun 2026

Lou Zexin, Wang Yu, Sun Mengtong, Li Guoxian, Li Jianing, Shi Yujie, Sun Ziqing, Liu Boyan, Zhao Hanqing, Ma Ze, Han Qiang, He Qida, Qiao Shigang, Shen Yueping

Abstract excerpt

BACKGROUND: Current knowledge on whether chronic pain contributes to atrial fibrillation (AF) risk, especially under varying genetic susceptibilities, is limited. This study aimed to explore the association between chronic pain and AF risk and assess the combined impact of chronic pain and genetic susceptibility to AF, as defined by polygenic risk scores (PRS), in the UK Biobank cohort. METHODS: We analyzed data...

Topics

Humans
Atrial Fibrillation
Female
Chronic Pain
Genetic Predisposition to Disease
Prospective Studies
Middle Aged
Genetic Risk Score
Risk Factors
Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Aged

United Kingdom

Risk Assessment

Time Factors

UK Biobank

Phenotype

Source

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Identifiers

PMID: 42226125
DOI: 10.1186/s12872-026-05994-4
PMCID: PMC13439901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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