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Article

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.

The Journal of biological chemistry - 29 Mar 2013

Lobo Glenn P, Amengual Jaume, Baus Diane, Shivdasani Ramesh A, Taylor Derek, von Lintig Johannes

Abstract excerpt

Low dietary intake of β-carotene is associated with chronic disease and vitamin A deficiency. β-Carotene is converted to vitamin A in the intestine by the enzyme β-carotene-15,15'-monoxygenase (BCMO1) to support vision, reproduction, immune function, and cell differentiation. Considerable variability for this key step in vitamin A metabolism, as reported in the human population, could be related to genetics and...

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Identifiers

PMID: 23393141
DOI: 10.1074/jbc.M112.444240
PMCID: PMC3610974

Genes

ISX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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