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PDLIM2 prevents the malignant phenotype of hepatocellular carcinoma cells by negatively regulating β-catenin.

Cancer gene therapy - 1 Nov 2021

Jiang Xiaoming, Chu Zhe, Cao Yang, Tang Ying, Shi Ying, Shi Xu

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most common malignancies and leading causes of cancer-related deaths globally. Despite significant advances in therapy, the molecular mechanisms underlying HCC development and progression remain unclear. Here, we aimed to explore the potential role of PDLIM2 in the development and epithelial-mesenchymal transition (EMT) of HCC via a possible modulation of β-catenin. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33398035
DOI: 10.1038/s41417-020-00257-6

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