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IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis.

Brain tumor pathology - 1 Jul 2023

Nakasu Satoshi, Deguchi Shoichi, Nakasu Yoko

Abstract excerpt

The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastoma (mGBM) if TERT promoter mutation (pTERTm), EGFR amplification or chromosome seven gain and ten loss aberrations are indicated. We systematically reviewed articles of IDHw hLGGs studies (49 studies, N = 3748) and meta-analyzed mGBM prevalence and overall survival (OS) according to the PRISMA...

Topics

Humans
Glioblastoma
Brain Neoplasms
Mutation
Isocitrate Dehydrogenase
Telomerase
Glioma
Prognosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37212969
DOI: 10.1007/s10014-023-00463-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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