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Article

The survival outcomes of molecular glioblastoma IDH-wildtype: a multicenter study.

Journal of neuro-oncology - 1 Mar 2022

Ramos-Fresnedo Andres, Pullen Michael W, Perez-Vega Carlos, Domingo Ricardo A, Akinduro Oluwaseun O, Almeida Joao P, Suarez-Meade Paola, Marenco-Hillembrand Lina, Jentoft Mark E, Bendok Bernard R, Trifiletti Daniel M, Chaichana Kaisorn L, Porter Alyx B, Quiñones-Hinojosa Alfredo, Burns Terence C, Kizilbash Sani H, Middlebrooks Erik H, Sherman Wendy J

Abstract excerpt

PURPOSE: Histological diagnosis of glioblastoma (GBM) was determined by the presence of necrosis or microvascular proliferation (histGBM). The 2021 WHO classification now considers IDH-wildtype diffuse astrocytic tumors without the histological features of glioblastoma (that would have otherwise been classified as grade 2 or 3) as molecular GBM (molGBM, WHO grade 4) if they harbor any of the following molecular...

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PMID: 35175545
DOI: 10.1007/s11060-022-03960-6

Genes

MGMT
EGFR
TERT

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