Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcobalamin receptor gene polymorphisms and mutation in an elderly population.

Clinical nutrition ESPEN - 1 Jun 2023

McCaddon Andrew, Carr Daniel F, Peter Hudson, Moat Stuart J, Quadros Edward V

Abstract excerpt

BACKGROUND & AIMS: Cellular uptake of the essential nutrient vitamin B12 (cobalamin) occurs via the transcobalamin receptor (TCblR/CD320), a ubiquitous membrane receptor. Polymorphisms in the receptor exist, though the effect of such variants across patient populations is unknown. METHODS: We determined CD320 genotype in 377 randomly selected elderly individuals. RESULTS: Three polymorphisms and a codon deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Folate and B Vitamins Research
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymorphism, Genetic

Share to Porphyrin Metabolism and Disorders

Share to Receptors, Cell Surface

Share to Vitamin B 12

Source

Identifiers

PMID: 37202078
DOI: 10.1016/j.clnesp.2023.04.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcobalamin receptor gene polymorphisms and mutation in an elderly population.PMID 37202078Read ↗

Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor geneSemantic proximity Read ↗

Association of Transcobalamin II (TCN2) and Transcobalamin II-Receptor (TCblR) Genetic Variations With Cobalamin Deficiency Parameters in Elderly Women.Semantic proximity Read ↗

Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12).Semantic proximity Read ↗

Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin.Semantic proximity Read ↗

Transcobalamin receptor defect: Identification of two new cases through positive newborn screening for propionic/methylmalonic aciduria and long-term outcome.Semantic proximity Read ↗

The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations.Semantic proximity Read ↗

Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.Semantic proximity Read ↗

Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults.Semantic proximity Read ↗

Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects.Semantic proximity Read ↗

The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status.Semantic proximity Read ↗

Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease.Semantic proximity Read ↗

Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.