Article
Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.
Neurology - 12 Mar 2013
Nuytemans Karen, Bademci Guney, Inchausti Vanessa, Dressen Amy, Kinnamon Daniel D, Mehta Arpit, Wang Liyong, Züchner Stephan, Beecham Gary W, Martin Eden R, Scott William K, Vance Jeffery M
Abstract excerpt
OBJECTIVE: Recently, vacuolar protein sorting 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) have been identified as 2 causal Parkinson disease (PD) genes. We used whole exome sequencing for rapid, parallel analysis of variations in these 2 genes. METHODS: We performed whole exome sequencing in 213 patients with PD and 272 control individuals. Those rare variants (RVs) with <5%...
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