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Article

Preserved autophagy in cognitively intact non‐demented individuals with Alzheimer's neuropathology

16 May 2023

Abstract excerpt

INTRODUCTION: Growing evidence supports that dysfunctional autophagy, the major cell mechanism responsible for removing protein aggregates and a route of clearance for Tau in healthy neurons, is a major finding in demented Alzheimer's disease (AD) patients. However, the association of autophagy with maintenance of cognitive integrity in resilient individuals who have AD neuropathology but remain non-demented...

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PMID: 37191183
DOI: 10.1002/alz.13074

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