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Article

Ultrasound-induced seizures in a mouse model of KCNQ2-NEO-DEE.

Epilepsy research - 1 Jul 2023

Brun Lucile, Borloz Emilie, Felix Marie-Solenne, Louis Durand Jordane, Villard Laurent

Abstract excerpt

PURPOSE: KCNQ2 neonatal developmental and epileptic encephalopathy (NEO-DEE) is characterized by intractable seizures accompanied by an abnormal neurodevelopment. In a mouse model of NEO-DEE carrying the p.(Thr274Met) variant of Kcnq2, spontaneous generalized seizures occur unexpectedly preventing controlled studies and highlighting the necessity for a customized setup to trigger seizures on demand. We aimed to...

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Source

Identifiers

PMID: 37187037
DOI: 10.1016/j.eplepsyres.2023.107160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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