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Soluble ORF2 protein enhances HEV replication and induces long-lasting antibody response and protective immunity in vivo

26 Apr 2023

Abstract excerpt

BACKGROUND AND AIMS: The HEV is a small positive-sense RNA virus that encodes a cytoplasmic form of the capsid protein (ORF2c), essential for virion structure, and a secreted glycosylated form (ORF2s) that accumulates at high titer in serum and can mask neutralizing epitopes. We explored the contribution of ORF2s to HEV replication and its role in generating antibodies against ORF2 in a nonhuman primate model....

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PMID: 37185268
DOI: 10.1097/hep.0000000000000421

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