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Diagnostic utility of DNA integrity number as an indicator of sufficient DNA quality in next-generation sequencing–based genomic profiling

30 Mar 2023

Abstract excerpt

OBJECTIVES: DNA integrity number (DIN) is a metric for assessing DNA degradation, calculated based on electrophoresis using the Agilent TapeStation System. The utility of DIN as a diagnostic indicator of sufficient DNA quality in clinical next-generation sequencing (NGS) has not been well described. METHODS: We evaluated the DINs of 166 tumor formalin-fixed, paraffin-embedded (FFPE) tissue samples submitted for...

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PMID: 37167067
DOI: 10.1093/ajcp/aqad046

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