Article
ALDH2 rs671 variant allele is associated with higher energy intake in middle-aged and elderly Japanese who routinely consume alcohol.
Environmental health and preventive medicine - 1 Jan 2023
Hayashida Hiroyuki, Matsumoto Akiko, Nanri Hinako, Nishida Yuichiro, Takagi Yusuke, Hara Megumi
Abstract excerpt
BACKGROUND: According to recent reports, individuals with reduced aldehyde dehydrogenase activity may require more energy for the detoxification of aldehydes. Aldehyde dehydrogenase 2 (ALDH2), an ALDH isozyme, is responsible for detoxifying acetaldehyde, an intermediate metabolite of ethanol. Because the variant allele of the rs671 polymorphism of ALDH2 results in a substantial reduction in enzymatic activity,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.