Article
Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa
1 Jan 2023
Abstract excerpt
In spermatozoa, the nuclear F-actin supports the acroplaxome, a subacrosomal structure involved in the correct exposure of several acrosomal membrane proteins; among them, the glycoprotein IZUMO1 is the major protein involved in sperm-oocyte fusion. Nuclear F-actin is also involved in sperm head shaping and chromosome compartmentalization. To date, few notions regarding the bivalent role of F-actin on sperm...
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