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Establishment of bovine trophoblast stem cells

1 May 2023

Abstract excerpt

Here, we report that a chemical cocktail (LCDM: leukemia inhibitory factor [LIF], CHIR99021, dimethinedene maleate [DiM], minocycline hydrochloride), previously developed for extended pluripotent stem cells (EPSCs) in mice and humans, enables de novo derivation and long-term culture of bovine trophoblast stem cells (TSCs). Bovine TSCs retain developmental potency to differentiate into mature trophoblast cells and...

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PMID: 37146606
DOI: 10.1016/j.celrep.2023.112439

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