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Article

Optical measurement of gating pore currents in hypokalemic periodic paralysis model cells.

Disease models & mechanisms - 1 Jun 2023

Kubota Tomoya, Takahashi Satoe, Yamamoto Risa, Sato Ruka, Miyanooto Aya, Yamamoto Reina, Yamauchi Kosuke, Homma Kazuaki, Takahashi Masanori P

Abstract excerpt

Hypokalemic periodic paralysis (HypoPP) is a rare genetic disease associated with mutations in CACNA1S or SCN4A encoding the voltage-gated Ca2+ channel Cav1.1 or the voltage-gated Na+ channel Nav1.4, respectively. Most HypoPP-associated missense changes occur at the arginine residues within the voltage-sensing domain (VSD) of these channels. It is established that such mutations destroy the hydrophobic seal that...

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Identifiers

PMID: 37139703
DOI: 10.1242/dmm.049704
PMCID: PMC10320719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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