Article

A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels

2017-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Skeletal muscle channelopathies, many of which are inherited as autosomal dominant mutations, include both myotonia and periodic paralysis. Myotonia is defined by a delayed relaxation after muscular contraction, whereas periodic paralysis is defined by episodic attacks of weakness. One sub-type of periodic paralysis, known as hypokalemic periodic paralysis (hypoPP), is associated with low potass...

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Literature Corpus work: ca0db04b-b96a-56b8-bd62-0a16a73f8a3f
DOI: 10.1101/164988

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