The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome.

doi:10.7554/eLife.84815

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome.

eLife - 3 May 2023

Chen Yiwang, Jiang Qi, Peierdun Mijiti, Takiff Howard E, Gao Qian

Abstract excerpt

Drug resistance is a known risk factor for poor tuberculosis (TB) treatment outcomes, but the contribution of other bacterial factors to poor outcomes in drug-susceptible TB is less well understood. Here, we generate a population-based dataset of drug-susceptible Mycobacterium tuberculosis (MTB) isolates from China to identify factors associated with poor treatment outcomes. We analyzed whole-genome sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Delayed Diagnosis
Share to Drug Resistance, Multiple, Bacterial
Share to Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium tuberculosis

Share to Treatment Outcome

Share to Tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 37133242
DOI: 10.7554/eLife.84815
PMCID: PMC10188106

Provenance

PubMed metadata and Literature Corpus relationships.