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Methylomic biomarkers of lithium response in bipolar disorder: a clinical utility study

29 Apr 2023

Abstract excerpt

BACKGROUND: Response to lithium (Li) is highly variable in bipolar disorders (BD). Despite decades of research, no clinical predictor(s) of response to Li prophylaxis have been consistently identified. Recently, we developed epigenetic Methylation Specific High-Resolution Melting (MS-HRM) assays able to discriminate good responders (GR) from non-responders (NR) to Li in individuals with BD type 1 (BD-I). This...

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PMID: 37119343
DOI: 10.1186/s40345-023-00296-6

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