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Article

IRX1 is a novel gene, overexpressed in high-grade IDH-mutant astrocytomas.

Pathology, research and practice - 1 May 2023

Sugur Harsha S, Rao Shilpa, Sravya Palavalasa, Athul Menon K, Arivazhagan Arimappamagan, Mehta Bhupesh, Santosh Vani

Abstract excerpt

BACKGROUND: IDH-mutant astrocytomas include CNS WHO grade 2 (A2), grade 3 (A3) and grade 4 (A4), of which A3 and A4 are high-grade. A3 has a heterogenous clinical outcome that cannot be explained entirely by the existing molecular biomarkers. We comprehensively studied the transcriptome profile of A3 to determine clinical significance. METHODS: TCGA mRNA-sequencing data of A3 was analyzed to derive differentially...

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PMID: 37116364
DOI: 10.1016/j.prp.2023.154464

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