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Article

Thoracic SMARCA4-deficient undifferentiated tumor

28 Apr 2023

Abstract excerpt

Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a recently described smoking-related malignancy. The pathogenesis of SMARCA4-UT is the mutational inactivation and loss of expression of a subunit encoding the mammalian switch/sucrose nonfermenting ATPase-dependent chromatin remodeling complex (which can be mobilized using adenosine triphosphate hydrolysis nucleosomes and regulate other cellular...

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PMID: 37115343
DOI: 10.1007/s12672-023-00639-w

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