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Article

IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients.

Genes - 7 Apr 2023

Carreño-Saavedra Noemi Magdalena, Reyes-Pérez Itzel Viridiana, Machado-Sulbaran Andrea Carolina, Martínez-Bonilla Gloria Esther, Ramírez-Dueñas María Guadalupe, Muñoz-Valle José Francisco, Olaya-Valdiviezo Valeria, García-Iglesias Trinidad, Martínez-García Erika Aurora, Sánchez-Hernández Pedro Ernesto

Abstract excerpt

Rheumatoid Arthritis (RA) is characterized by joint destruction, chronic inflammation, and autoantibody production. IL-21/IL-21R plays an essential role in the immunopathology of RA. Elevated IL-21 serum levels have been associated with RA and disease activity. Here, we evaluated the association of IL-21/IL-21R polymorphisms and IL-21 serum levels with RA. The study included 275 RA patients and 280 Control...

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Identifiers

PMID: 37107636
DOI: 10.3390/genes14040878
PMCID: PMC10137781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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