Article
IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility.
Bioscience reports - 31 Jan 2020
Yu Menglei, Hou Jingyi, Zheng Minghui, Cao Yi, Alike Yamuhanmode, Mi Yuanyuan, Zhu Jie
Abstract excerpt
Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymorphism and RA risk. Thus, it's necessary to perform a meta-analysis to definite above...
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