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Article

The Type I Interferon Signature Reflects Multiple Phenotypic and Activity Measures in Dermatomyositis

25 Apr 2023

Abstract excerpt

OBJECTIVE: The type 1 interferon (IFN) pathway is up-regulated in dermatomyositis (DM). We sought to define how organ-specific disease activity as well as autoantibodies and other clinical factors are independently associated with systemic type I IFN activity in adult patients with DM. METHODS: RNA sequencing was performed on 355 whole blood samples collected from 202 well-phenotyped DM patients followed up...

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PMID: 37096447
DOI: 10.1002/art.42526

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