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Article

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.

Blood - 8 Nov 2012

Kuriyama Takuro, Takenaka Katsuto, Kohno Kentaro, Yamauchi Takuji, Daitoku Shinya, Yoshimoto Goichi, Kikushige Yoshikane, Kishimoto Junji, Abe Yasunobu, Harada Naoki, Miyamoto Toshihiro, Iwasaki Hiromi, Teshima Takanori, Akashi Koichi

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is characterized by deregulated engulfment of hematopoietic stem cells (HSCs) by BM macrophages, which are activated presumably by systemic inflammatory hypercytokinemia. In the present study, we show that the pathogenesis of HLH involves impairment of the antiphagocytic system operated by an interaction between surface CD47 and signal regulatory protein α (SIRPA). In HLH...

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Source

Identifiers

PMID: 22990013
DOI: 10.1182/blood-2012-02-408864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.PMID 22990013Read ↗

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