Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury.

Nephron - 1 Jan 2017

Hukriede Neil, Vogt Andreas, de Caestecker Mark

Abstract excerpt

The cellular responses that occur following acute kidney injury (AKI) are complex and dynamic, involving multiple cells types and molecular pathways. For this reason, early selection of defined molecular targets for therapeutic intervention is unlikely to be effective in complex in vivo models of AKI, let alone Phase 3 clinical trials in patients with even more complex AKI pathobiology. Phenotypic screening using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Discovery

Share to Phenotype

Share to Renal Insufficiency, Chronic

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 28614822
DOI: 10.1159/000476079
PMCID: PMC7197487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury.PMID 28614822Read ↗

Translating Knowledge Into Therapy for Acute Kidney Injury.Semantic proximity Read ↗

Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical GeneticsSemantic proximity Read ↗

Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney InjurySemantic proximity Read ↗

Zebrafish (Danio rerio) as a model organism for screening nephrotoxic chemicals and related mechanismsSemantic proximity Read ↗

Acute renal failure in zebrafish: a novel system to study a complex diseaseSemantic proximity Read ↗

Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.Semantic proximity Read ↗

Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic ToxinsSemantic proximity Read ↗

Flight for fish in drug discovery: a review of zebrafish-based screening of molecules.Semantic proximity Read ↗

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved DrugsSemantic proximity Read ↗

In vivo high-content screening in zebrafish for developmental nephrotoxicity of approved drugsSemantic proximity Read ↗

Clinical trials for acute kidney injury: design challenges and possible solutions.Semantic proximity Read ↗

Implementation of a human podocyte injury model of chronic kidney disease for profiling of renoprotective compounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.