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Article

Dedifferentiation maintains melanocyte stem cells in a dynamic niche

19 Apr 2023

Abstract excerpt

Abstract For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult stem cell populations1, which leads to hair greying in most humans and mice2,3. Current dogma states that McSCs are reserved in an undifferentiated state in the hair follicle niche, physically segregated from differentiated progeny that migrate away following cues of regenerative stimuli4–8. Here we show that most...

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PMID: 37076619
DOI: 10.1038/s41586-023-05960-6

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