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Article

Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus.

Aging - 18 Apr 2023

Loika Yury, Loiko Elena, Feng Fan, Stallard Eric, Yashin Anatoliy I, Arbeev Konstantin, Kuipers Allison L, Feitosa Mary F, Province Michael A, Kulminski Alexander M

Abstract excerpt

Associations of single nucleotide polymorphisms (SNPs) of the MLXIPL lipid gene with Alzheimer's (AD) and coronary heart disease (CHD) and potentially causal mediation effects of their risk factors, high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), were examined in two samples of European ancestry from the US (22,712 individuals 587/2,608 AD/CHD cases) and the UK Biobank (UKB) (232,341...

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Identifiers

PMID: 37074818
DOI: 10.18632/aging.204665
PMCID: PMC10449285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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