Article
Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Jun 2023
Farrell Scott F, Sterling Michele, Klyne David M, Mustafa Sanam, Campos Adrián I, Kho Pik-Fang, Lundberg Mischa, Rentería Miguel E, Ngo Trung Thanh, Cuéllar-Partida Gabriel
Abstract excerpt
PURPOSE: Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions. METHODS: Using genome-wide...
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