Article
Causal evidence linking chronic pain genetics to late-onset asthma via the nervous system.
British journal of anaesthesia - 1 Mar 2026
Kolifarhood Goodarz, Parisien Marc, Fillingim Matt, Chen Charlise, Chen Yiran, Dimitrov Nikolay, Zidan Maha, Hanumunthadu Lovéni, Her Peter H, Bhatnagar Sahir, Diatchenko Luda, Grant Audrey V
Abstract excerpt
BACKGROUND: Chronic pain and asthma are associated, but the direction and basis of their genetic and biological relationship remain unclear. METHODS: We conducted genome-wide association studies (GWAS), multi-trait analysis of GWAS (MTAG), polygenic risk score (PRS) prediction, bivariate causal modelling, and Mendelian randomisation (MR) across nine chronic pain traits and three asthma age-of-onset strata (<18,...
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